Pharmacological studies on centrally-acting drugs belonging to enaminone mannich bases. II. Pharmacology of MK 1-203 and 1-907, new potent analgesics
نویسندگان
چکیده
منابع مشابه
New centrally acting antihypertensive drugs related to methyldopa and clonidine.
It has been well established that the antihypertensive drugs clonidine and methyldopa lower blood pressure by acting on postsynaptic alpha 2-adrenergic receptors within cardiovascular control centers of the brain. A number of novel agents designed as lipophilic and highly selective alpha 2-adrenergic stimulants have been synthesized and in general the pharmacological features of these agents re...
متن کاملSynthesis and Biological Activity of Certain Mannich Bases Derivatives from 1, 2, 4-Triazoles
Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Tr...
متن کاملCritical flicker frequency and centrally-acting drugs.
THE critical flicker frequency (cff) may be defined as the fastest rate at which a flickering source of light appears to be flickering as opposed to being steady. It has a number of determinants including the luminance, wave-length, wave-form, and light-dark ratio of the stimulating light, the area, position, and light-adapted state of the retina illuminated, the duration of exposure, and the s...
متن کاملEffect of four centrally acting drugs on handwriting.
Writing is a motor act which is acquired early in life and the performance thereafter remains stable over long periods of time in adult individuals. Successive samples are, thus unlikely to be affected by further practice (1). At the same time, handwriting, being a complex motor act requiring fine co-ordination should be more sensitive to the effects of psychoactive agents than simple skills (2...
متن کاملStudies on the Anthelmintic Property of Aminobenzylated Mannich Bases
Studies were conducted on the anthelmintic property of about 15(e-h, 1e-1h, 2d-2f and 3e-3h) synthesized aminobenzylated Mannich bases bearing N-methyl piperazine using Indian earthworms Pheritima Posthuma against piperazine citrate as standard reference. Three concentrations of each compound (0.1, 0.2, 0.3% w/v) were studied, which involved the determination of paralysis and death time of the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1974
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)32266-8